Brand Name | Status | Last Update |
---|---|---|
clariscan | ANDA | 2024-09-17 |
dotarem | New Drug Application | 2025-03-14 |
gadoterate meglumine | ANDA | 2025-04-16 |
Code | Description |
---|---|
A9575 | Injection, gadoterate meglumine, 0.1 ml |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Prostatic neoplasms | D011471 | — | C61 | 1 | 1 | 2 | 1 | 2 | 6 |
Lymphatic metastasis | D008207 | EFO_1001364 | — | 1 | 1 | 1 | 1 | 3 | 6 |
Magnetic resonance imaging | D008279 | — | — | — | — | — | 2 | 3 | 5 |
Brain neoplasms | D001932 | EFO_0003833 | C71 | — | 1 | 1 | 1 | 1 | 4 |
Renal insufficiency | D051437 | — | N19 | 1 | 1 | — | 2 | 1 | 4 |
Hepatocellular carcinoma | D006528 | — | C22.0 | — | — | — | 1 | 2 | 3 |
Liver neoplasms | D008113 | EFO_1001513 | C22.0 | — | — | — | 1 | 2 | 3 |
Peripheral arterial disease | D058729 | EFO_0004265 | — | — | — | — | 2 | — | 2 |
Peripheral vascular diseases | D016491 | EFO_0003875 | I73.9 | — | — | — | 2 | — | 2 |
Breast diseases | D001941 | — | N60-N65 | 1 | — | — | 1 | — | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | 1 | — | 1 | 4 |
Urinary bladder neoplasms | D001749 | — | C67 | 1 | 1 | 1 | — | 1 | 3 |
Neoplasms | D009369 | — | C80 | 1 | 1 | 1 | — | 1 | 3 |
Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | 1 | — | 1 | 3 |
Body weight | D001835 | EFO_0004338 | — | — | — | 1 | — | 1 | 2 |
Neoplasm metastasis | D009362 | EFO_0009708 | — | — | — | 2 | — | — | 2 |
Central nervous system diseases | D002493 | — | G96.9 | — | — | 2 | — | — | 2 |
Cerebral arterial diseases | D002539 | EFO_1000859 | — | — | — | 2 | — | — | 2 |
Rectal neoplasms | D012004 | — | — | — | 1 | 1 | — | — | 2 |
Aneurysm | D000783 | — | I72.9 | — | 1 | 1 | — | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Uterine cervical neoplasms | D002583 | — | — | 2 | 2 | — | — | 1 | 3 |
Inflammation | D007249 | MP_0001845 | — | 1 | 1 | — | — | — | 2 |
Carcinoma | D002277 | — | C80.0 | 1 | 1 | — | — | 1 | 2 |
Squamous cell carcinoma of head and neck | D000077195 | — | — | 1 | 1 | — | — | 1 | 2 |
Chronic renal insufficiency | D051436 | — | N18 | 1 | 1 | — | — | 1 | 2 |
Hip fractures | D006620 | EFO_0003964 | S72.00 | 1 | 1 | — | — | — | 2 |
Local anesthesia | D000772 | — | — | 1 | 1 | — | — | — | 2 |
Endometrial neoplasms | D016889 | EFO_0004230 | — | 1 | 1 | — | — | 1 | 2 |
Fibrosis | D005355 | — | — | — | 1 | — | — | 1 | 2 |
Uterine neoplasms | D014594 | EFO_0003859 | C55 | 1 | 1 | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Multiple sclerosis | D009103 | EFO_0003885 | G35 | 1 | — | — | — | 1 | 2 |
Sclerosis | D012598 | — | — | 1 | — | — | — | 1 | 2 |
Fibroadenoma | D018226 | — | — | 1 | — | — | — | — | 1 |
Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
Heart failure | D006333 | EFO_0003144 | I50 | 1 | — | — | — | — | 1 |
Left ventricular hypertrophy | D017379 | EFO_0003896 | — | 1 | — | — | — | — | 1 |
Myocardial infarction | D009203 | EFO_0000612 | I21 | 1 | — | — | — | — | 1 |
Infarction | D007238 | EFO_0009463 | — | 1 | — | — | — | — | 1 |
Hypertrophy | D006984 | EFO_0002460 | — | 1 | — | — | — | — | 1 |
Pain | D010146 | EFO_0003843 | R52 | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Cardiomyopathies | D009202 | EFO_0000318 | I42 | — | — | — | — | 2 | 2 |
Liver cirrhosis | D008103 | EFO_0001422 | K74.0 | — | — | — | — | 2 | 2 |
Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | — | — | — | 2 | 2 |
Ovarian epithelial carcinoma | D000077216 | — | — | — | — | — | — | 2 | 2 |
Takotsubo cardiomyopathy | D054549 | EFO_1002000 | I51.81 | — | — | — | — | 1 | 1 |
Male breast neoplasms | D018567 | — | — | — | — | — | — | 1 | 1 |
Autoimmune diseases | D001327 | EFO_0000540 | M30-M36 | — | — | — | — | 1 | 1 |
Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | — | — | — | — | 1 | 1 |
Myocardial perfusion imaging | D055414 | — | — | — | — | — | — | 1 | 1 |
Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 1 | 1 |
Drug common name | Gadoterate meglumine |
INN | _ |
Description | Gadoteric acid, sold under the brand name Dotarem among others, is a macrocycle-structured gadolinium-based MRI contrast agent (GBCA). It consists of the organic acid DOTA as a chelating agent, and gadolinium (Gd3+), and is used in form of the meglumine salt (gadoterate meglumine). The paramagnetic property of gadoteric acid reduces the T1 relaxation time (and to some extent the T2 and T2* relaxation times) in MRI, which is the source of its clinical utility. Because it has magnetic properties, gadoteric acid develops a magnetic moment when put under a magnetic field, which increases the signal intensity (brightness) of tissues during MRI imaging.
|
Classification | Small molecule |
Drug class | gadolinium derivatives (principally for diagnostic use) |
Image (chem structure or protein) | ![]() |
Structure (InChI/SMILES or Protein Sequence) | — |
PDB | — |
CAS-ID | 72573-82-1 |
RxCUI | — |
ChEMBL ID | CHEMBL2219415 |
ChEBI ID | 73727 |
PubChem CID | 158536 |
DrugBank | DB09132 |
UNII ID | L0ND3981AG (ChemIDplus, GSRS) |